o-(Trifluoromethyl)benzaldehyde → HCID 57434515, compound

HRID 2056398Notes

Reaction equation

HRID 2056398 reaction equation
[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][C:17](C)=[CH:16][CH:15]=2)[O:6][C:7]=1[C:8]1C=CC=CC=1.C/C(/C(C)=O)=N\O.[F:28][C:29]([F:39])([F:38])C1C=CC=CC=1C=O>>[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:19]=2[C:29]([F:39])([F:38])[F:28])[O:6][C:7]=1[CH3:8]

Participants

4

Reactant 3

HCID 123067o-(Trifluoromethyl)benzaldehydeHCID 64096332,3-Butanedione monoximeHCID 574345044-Iodomethyl-5-phenyl-2-p-tolyloxazole

Product 1

HCID 57434515HCID 57434515, compound

Procedure

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyl-oxazole, diacetylmonoxime and 2-trifluoromethylbenzaldehyde gave 4-iodomethyl-5-methyl-2-(2-trifluoromethylphenyl)oxazole.

Sources & evidence

ORD record
ord-4169ce8d08b04ccf99fb8f40d89b4c4b
Source dataset
uspto-grants-2008_02
Patent number
US07335671B2

Reaction notes

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