4-Methyl-1-piperazinecarbonyl chloride → 6-[4-[(4-Methylpiperazin-1-yl)carbonyl]piperazin-1-yl]pyridazine-3-carboxylic acid (3-methylbutyl)amide

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Reaction Steps

Following the procedure of Example 3, making variations only as required to use 4-methylpiperazine-1-carbonyl chloride in place of isoxazole-5-carbonyl chloride to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (3-methylbutyl)amide, the title compound was obtained as a white powder (79% yield). 1H NMR (300 MHz, CDCl3) δ 8.01, 7.83, 6.96, 3.77-3.73, 3.51-3.44, 3.42-3.38, 3.36-3.33, 2.44-2.41, 2.31, 1.75-1.62, 1.48, 0.92. MS (ES+) m/z 404.4 (M+1).

Provenance & Evidence