HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-methyl-5-(trifluoromethyl)-1,3-oxazole-4-carboxylic Acid → HCID 11259513, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-methyl-5-(trifluoromethyl)-1,3-oxazole-4-carboxylic Acid | HCID 2775651 | — |
| Reactant | N-(2-cyclopropylethyl)-6-(1-piperazinyl)-3-pyridazinecarboxamide | HCID 66849327 | — |
| Product | HCID 11259513 | HCID 11259513 | — |
Reaction Steps
Following the procedure of Example 9, making variations only as required to use 2-methyl-5-trifluoromethyloxazole-4-carboxylic acid in place of 2,5-dichlorobenzoic acid to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide, the title compound was obtained as a white solid (58% yield). 1H NMR (300 MHz, CDCl3) δ 8.05, 7.98, 6.99, 3.75-3.95, 3.50-3.59, 2.55, 1.51, 0.71-0.80, 0.45-0.49, 0.06-0.12. MS (ES+) m/z 453 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07335658B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-34fb06192b7942b19b94a128cc0737fb |
| Source note | uspto-grants-2008_02 |