HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-1-(chloromethyl)-4-fluorobenzene → HCID 67012125, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-1-(chloromethyl)-4-fluorobenzene | HCID 2725064 | — |
| Reactant | N-(2-cyclopropylethyl)-6-(1-piperazinyl)-3-pyridazinecarboxamide | HCID 66849327 | — |
| Product | HCID 67012125 | HCID 67012125 | — |
Reaction Steps
Following the procedure of Example 11, making variations only as required to use 2-chloro-4-fluorobenzyl chloride in place of 2-trifluoromethylbenzyl chloride to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide, the title compound was obtained as a white solid (26% yield). 1H NMR (300 MHz, CDCl3) δ 7.92-8.03, 7.38-7.50, 7.06-7.14, 6.88-7.03, 3.68-3.78, 3.62, 3.46-3.58, 2.55-2.69, 1.42-1.54, 0.68-0.80, 0.40-0.49, 0.02-0.13. MS (ES+) m/z 418 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07335658B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-e494a6ed4ab04a1490a2e4d510f922fb |
| Source note | uspto-grants-2008_02 |