HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[2-(Trifluoromethyl)benzoyl]piperazine → 4-METHYL-2-({6-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]-PYRIDAZINE-3-CARBONYL}AMINO)PENTANOIC Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[2-(Trifluoromethyl)benzoyl]piperazine | HCID 16733784 | — |
| Reactant | 2-[(6-Chloropyridazine-3-carbonyl)amino]-4-methylpentanoic acid methyl ester | HCID 61041855 | — |
| Product | 4-METHYL-2-({6-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]-PYRIDAZINE-3-CARBONYL}AMINO)PENTANOIC Acid Methyl Ester | HCID 16035764 | — |
Reaction Steps
Following the procedure of Example 15, making variations only as required to use 2-[(6-chloropyridazine-3-carbonyl)amino]-4-methylpentanoic acid methyl ester in place of 6-chloropyridazine-3-carboxylic acid (2-cyclopropyl-2-hydroxyethyl)amide to react with piperazin-1-yl-(2-trifluoromethylphenyl)-methanone, the title compound was obtained as a white solid (36% yield). 1H NMR (400 MHz, CDCl3) δ 8.16, 8.04, 7.85, 7.66-7.53, 7.28, 7.00, 4.82-4.77, 4.14-3.68, 3.58-3.51, 1.83-1.60, 1.03-0.95.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07335658B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-b2ea8fee746f4edfa5cbb0d0e3524f74 |
| Source note | uspto-grants-2008_02 |