Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-[2-(Trifluoromethyl)benzoyl]piperazine → 6-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (2-PHENYLCYCLOPROPYLMETHYL)AMIDE
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-[2-(Trifluoromethyl)benzoyl]piperazine | HCID 16733784 | — |
| 반응물 | 6-Chloropyridazine-3-carboxylic acid (2-phenylcyclopropylmethyl)amide | HCID 86025948 | — |
| 생성물 | 6-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (2-PHENYLCYCLOPROPYLMETHYL)AMIDE | HCID 11295159 | — |
반응 단계
Following the procedure of Example 15, making variations only as required to use 6-chloropyridazine-3-carboxylic acid (2-phenylcyclopropylmethyl)amide in place of 6-chloropyridazine-3-carboxylic acid (2-cyclopropyl-2-hydroxyethyl)amide to react with piperazin-1-yl-(2-trifluoromethylphenyl)methanone, the title compound was obtained as a white solid (25% yield). 1H NMR (400 MHz, CDCl3) δ 8.09-8.03, 7.76, 7.64, 7.57, 7.36, 7.28-7.21, 7.17-7.12, 7.07-6.96, 4.09-3.32, 1.92-1.86, 1.47-1.38, 1.01-0.96. MS (ES+) m/z 510.4 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07335658B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-5a3b2f3597354ce2a0a061cec53bed86 |
| 출처 메모 | uspto-grants-2008_02 |