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6-chloro-N-(3-methylbutyl)pyridazine-3-carboxamide → 6-[4-(2,6-DIFLUOROBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (3-METHYLBUTYL)AMIDE
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-chloro-N-(3-methylbutyl)pyridazine-3-carboxamide | HCID 16733786 | — |
| 反応物 | 1-(2,6-Difluorobenzoyl)piperazine | HCID 18362750 | — |
| 生成物 | 6-[4-(2,6-DIFLUOROBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (3-METHYLBUTYL)AMIDE | HCID 11618568 | — |
反応手順
Following the procedure of Example 15, making variations only as required to use 6-chloropyridazine-3-carboxylic acid (3-methylbutyl)amide in place of 6-chloropyridazine-3-carboxylic acid (2-cyclopropyl-2-hydroxyethyl)amide to react with piperazin-1-yl-(2,6-difluorophenyl)methanone, the title compound was obtained as a white powder (42.2% yield). 1H NMR (400 MHz, CDCl3) δ 8.07, 7.85, 7.44-7.38, 7.03-6.97, 4.0-3.99, 3.86-3.83, 3.52-3.48, 1.73-1.67, 1.51, 0.94.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07335658B2 |
| 出典データセット | uspto-grants-2008_02 |
| ORD ID | ord-cdd6dccc0a5d4a16a2e40751675545f2 |
| 出典メモ | uspto-grants-2008_02 |