HCID 16734358, compound → HCID 69220416, compound

Participants

Reaction Steps

63 ml of a freshly prepared 0.65 M cerium ammonium nitrate solution is added, dropwise, to 3.8 g (13.1 mmol) of 2-(4-fluorophenyl)-4,6-dimethoxy-1,3-benzothiazole in solution in 100 ml of ethyl acetate. The reaction mixture is maintained under stirring at ambient temperature for 3 hours then the aqueous phase is separated and washed with 3 times 75 ml of ethyl acetate. The organic phases are combined, dried over sodium sulphate and the solvents are evaporated off under reduced pressure. The residue is purified by chromatography on a silica column (eluent: ethyl acetate/heptane mixture 1:3) in order to provide 0.6 g (16% yield) of expected product.

Provenance & Evidence