Methyl iodide → Methyl 2,5-difluorobenzene carbimidothioate hydroiodide
Reaction equation
[CH3:1][I:2].[F:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11](=[S:13])[NH2:12]>CC(C)=O>[IH:2].[F:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]([S:13][CH3:1])=[NH:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 25 °C
Procedure
5.9 ml (94.2 mmol; 1.5 equivalents) of methyl iodide is added to 10.8 g (62 mmol) of 2,5-difluorobenzenecarbothioamide in solution in 70 ml of acetone. The reaction mixture is maintained under stirring at 25° C. for 24 hours, then the solvent is evaporated off under reduced pressure. Methyl 2,5-difluorobenzene carbimidothioate hydroiodide is obtained (18.4 g; yield=93%), after crystallization from ethyl ether, in the form of beige powder.
Workup
- temperatureThe reaction mixture is maintained
- customthe solvent is evaporated off under reduced pressure
Sources & evidence
- ORD record
- ord-2dfc3de3aaa642c9997e8f088ceb13e3
- Source dataset
- uspto-grants-2008_02
- Patent number
- US07335674B2
Reaction notes
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