Water → HCID 67393523, compound

HRID 2056628Notes

Reaction equation

FC(F)(F)C(OC1C(OC(=O)C(F)(F)F)=C(I)C=CC=1)=[O:4].[F:22][C:23]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=1[C:30]1[O:31][C:32]2[C:38](N)=[C:37]([O:40][CH3:41])[CH:36]=[CH:35][C:33]=2[N:34]=1.[OH2:42]>C(#N)C.O>[F:22][C:23]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=1[C:30]1[O:42][C:35]2[C:36](=[O:4])[C:37]([O:40][CH3:41])=[CH:38][C:32](=[O:31])[C:33]=2[N:34]=1

Participants

Conditions

Temperature: -5 °C

Procedure

2.9 g (6.81 mmol; 2.2 equivalents) of bis(trifluoroacetoxy)iodo benzene dissolved in 75 ml of an acetonitrile/water mixture 4:1 is added dropwise to a solution of 0.86 g (3.10 mmol) of 2-(2,5-difluorophenyl)-6-methoxy-1,3-benzoxazol-7-amine in 30 ml of an acetonitrile/water mixture 4:1 at −5° C. After stirring for 30 minutes at −5° C., 70 ml of water is added to the reaction medium and the product formed is extracted twice with 100 ml of dichloromethane. The organic phases are combined and dried over sodium sulphate, then the solvents are evaporated off under reduced pressure. The residue is then purified by chromatography on a silica column (eluent: dichloromethane/methanol mixture 99:1) and 475 mg (yield=53%) of 2-(2,5-difluorophenyl)-6-methoxy-1,3-benzoxazole-4,7-dione is obtained in the form of a yellow powder.

Workup

customthe product formed
extractionis extracted twice with 100 ml of dichloromethane
dry with materialdried over sodium sulphate
customthe solvents are evaporated off under reduced pressure
customThe residue is then purified by chromatography on a silica column (eluent: dichloromethane/methanol mixture 99:1)

Sources & evidence

ORD record: ord-ddbe0b099be647de9289ec2f7a1ab81d
Source dataset: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07335674B2

Reaction notes

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