Ethyl (3-nitrophenyl)acetate → Ethyl 2-(3-aminophenyl)acetate

Participants

Reaction Steps

Thus obtained ethyl 3-nitrophenylacetate (5.0 g, 24 mmol) was then dissolved in methanol (80 mL) together with 10 wt % of palladium/carbon (150 mg), and stirred under a hydrogen atmosphere (1 kg/cm2) for 14 hours. The reaction solution was filtered through Celite so as to remove the palladium/carbon catalyst, evaporated under reduced pressure so as to remove the solvent, and the residue was purified through silica gel column chromatography (hexane:ethyl acetate (v/v)=7:3) to thereby obtain a purified ethyl 3-aminophenylacetate (yield: 4.0 g, yield ratio: 100%) as a syrup.

Provenance & Evidence