3-amino-5-hydroxyquinoxalin-2(1H)-one → (S)-3-amino-5-(6-chloro-2-(1-methoxypropan-2-ylamino)pyrimidin-4-yloxy)quinoxalin-2(1H)-one

Participants

Reaction Steps

The reaction of (S)-4,6-dichloro-N-(1-methoxypropan-2-yl)pyrimidin-2-amine from step (a) above (0.62 g, 2.63 mmol) with 3-amino-5-hydroxyquinoxalin-2(1H)-one (0.47 g, 3 mmol, prepared as described in WO 2004/014871) under the conditions of Example 105(a) provided the title compound as an off-white solid. MS (ESI, pos. ion.) m/z: 377 (M+1).

Provenance & Evidence