tert-Butyl 2-(aminomethyl)piperidine-1-carboxylate → HCID 58612032, compound

HRID 2056710Notes

Reaction equation

HRID 2056710 reaction equation
[NH2:1][C:2]1[C:3](=[O:30])[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([O:12][C:13]1[CH:18]=[C:17]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=3)[N:16]=[C:15](Cl)[N:14]=1)[CH:8]=[CH:7][CH:6]=2.[NH2:31][CH2:32][CH:33]1[CH2:38][CH2:37][CH2:36][CH2:35][N:34]1[C:39]([O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[O:40]>>[NH2:1][C:2]1[C:3](=[O:30])[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([O:12][C:13]1[CH:18]=[C:17]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=3)[N:16]=[C:15]([NH:31][CH2:32][CH:33]3[CH2:38][CH2:37][CH2:36][CH2:35][N:34]3[C:39]([O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[O:40])[N:14]=1)[CH:8]=[CH:7][CH:6]=2

Participants

3

Reactant 2

HCID 2756482tert-Butyl 2-(aminomethyl)piperidine-1-carboxylateHCID 58612074HCID 58612074, compound

Product 1

HCID 58612032HCID 58612032, compound

Procedure

The reaction of 3-amino-5-(2-chloro-6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one (433 mg, 1.0 mmol, Example 106(a)) with tert-butyl 2-(aminomethyl)piperidine-1-carboxylate (428 mg, 2 mmol, Fluorochem) under the conditions of Example 34 provided the title compound as an amorphous solid. MS (ESI, pos. ion) m/z: 612 (M+1).

Sources & evidence

ORD record
ord-b379ff3711d9419f9373b1c5185cda2a
Source dataset
uspto-grants-2008_02
Patent number
US07335672B2

Reaction notes

Loading…