Cyclopropanecarboxaldehyde → HCID 11706509, compound

HRID 2056713Notes

Reaction equation

[NH2:1][C:2]1[C:3](=[O:35])[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([O:12][C:13]1[CH:18]=[C:17]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=3)[N:16]=[C:15]([N:29]3[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]3)[N:14]=1)[CH:8]=[CH:7][CH:6]=2.[CH:36]1([CH:39]=O)[CH2:38][CH2:37]1>>[NH2:1][C:2]1[C:3](=[O:35])[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([O:12][C:13]1[CH:18]=[C:17]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=3)[N:16]=[C:15]([N:29]3[CH2:34][CH2:33][N:32]([CH2:39][CH:36]4[CH2:38][CH2:37]4)[CH2:31][CH2:30]3)[N:14]=1)[CH:8]=[CH:7][CH:6]=2

Participants

Reactant 2

HCID 123114Cyclopropanecarboxaldehyde

HCID 11562108HCID 11562108, compound

Product 1

HCID 11706509HCID 11706509, compound

Procedure

The reaction of 3-amino-5-(2-(piperazin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one (27 mg, 0.056 mmol, Example 135) with cyclopropanecarboxaldehyde (59 mg, 0.279 mmol, Aldrich) under the conditions of Example 36 provided the title compound as an amorphous solid. MS (ESI, pos. ion) m/z: 538 (M+1).

Sources & evidence

ORD record: ord-1aa936d341574c2f83a84c1bc6d8c530
Source dataset: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07335672B2

Reaction notes

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