HRID2056716

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID17750437

tert-Butyl (2S)-2-(2-methylpropyl)piperazine-1-carboxylate

C13H26N2O2

结构：COC[C@H](C)Nc1nc(Cl)cc(Oc2cccc3[nH]c(=O)c(N)nc23)n1

HCID58612053

未命名化合物

PRODUCTS

生成物

结构：COC[C@H](C)Nc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(N2CCN(C(=O)OC(C)(C)C)[C@@H](CC(C)C)C2)n1

HCID58612011

未命名化合物

PROCEDURE

实验过程

The reaction of (S)-3-amino-5-(6-chloro-2-(1-methoxypropan-2-ylamino)pyrimidin-4-yloxy)quinoxalin-2(1H)-one (74 mg, 0.2 mmol, Example 122(b)) with (S)-tert-butyl 2-isobutylpiperazine-1-carboxylate (48 mg, 0.2 mmol, CNH-Tech) under the conditions of Example 34 provided the title compound as an amorphous solid. MS (ESI, pos. ion) m/z: 583 (M+1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-be4e70192b9241909c41a386d8ac5dd5
来源数据集: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07335672B2
来源说明: uspto-grants-2008_02

反应 SMILES

[NH2:1][C:2]1[C:3](=[O:26])[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([O:12][C:13]1[CH:18]=[C:17](Cl)[N:16]=[C:15]([NH:20][C@@H:21]([CH3:25])[CH2:22][O:23][CH3:24])[N:14]=1)[CH:8]=[CH:7][CH:6]=2.[CH2:27]([C@H:31]1[CH2:36][NH:35][CH2:34][CH2:33][N:32]1[C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])[CH:28]([CH3:30])[CH3:29]>>[NH2:1][C:2]1[C:3](=[O:26])[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([O:12][C:13]1[N:14]=[C:15]([NH:20][C@@H:21]([CH3:25])[CH2:22][O:23][CH3:24])[N:16]=[C:17]([N:35]3[CH2:34][CH2:33][N:32]([C:37]([O:39][C:40]([CH3:41])([CH3:42])[CH3:43])=[O:38])[C@@H:31]([CH2:27][CH:28]([CH3:30])[CH3:29])[CH2:36]3)[CH:18]=1)[CH:8]=[CH:7][CH:6]=2