Cornforth reagent → HCID 69307294, compound

Participants

Reaction Steps

To a solution of (1S)-1-{2-[(2R)-4-(1-hydroxy-1,2-dihydro-5-acenaphthylenyl)-2-methylpiperazinyl]ethyl}-3,4-dihydro-1H-2-benzopyran-6-carboxamide (0.10 g, 0.21 mmol) in dry DMF (2 mL), cooled to 0° C. under nitrogen, was added pyridinium dichromate (0.08 g, 0.21 mmol), and the mixture stirred for 4 h, allowing the reaction to warm to room temperature. A further equivalent of pyridinium dichromate was added and the reaction stirred for a further 1 h. The mixture was poured onto water and the resultant precipitate filtered off. Purification by preparative LC-MS yielded (1S)-1-{2-[(2R)-2-methyl-4-(1-oxo-1,2-dihydro-5-acenaphthylenyl)piperazinyl]ethyl}-3,4-dihydro-1H-2-benzopyran-6-carboxamide. M+H=470.

Provenance & Evidence