2-(5-Chloro-1,3-dihydro-2-benzofuran-1-yl)ethanol → Tert-butyl-[2-(5-chloro-1,3-dihydro-2-benzofuran-1-yl)ethoxy]-dimethylsilane

HRID 2056747Notes

Reaction equation

HRID 2056747 reaction equation
[Cl:1][C:2]1[CH:13]=[CH:12][C:5]2[CH:6]([CH2:9][CH2:10][OH:11])[O:7][CH2:8][C:4]=2[CH:3]=1.[Si:14](OCC[C@H]1C2C=CC(Br)=CC=2CCO1)([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15]>>[C:17]([Si:14]([O:11][CH2:10][CH2:9][CH:6]1[C:5]2[CH:12]=[CH:13][C:2]([Cl:1])=[CH:3][C:4]=2[CH2:8][O:7]1)([CH3:16])[CH3:15])([CH3:20])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 693065152-(5-Chloro-1,3-dihydro-2-benzofuran-1-yl)ethanolHCID 69307753(1S)-6-Bromo-3,4-dihydro-1H-2-benzopyran-1-yl-ethyl tert-butyl(dimethyl)silyl ether

Product 1

HCID 69307285Tert-butyl-[2-(5-chloro-1,3-dihydro-2-benzofuran-1-yl)ethoxy]-dimethylsilane

Procedure

Prepared from 2-(5-chloro-1,3-dihydro-2-benzofuran-1-yl)ethanol, as described for the preparation of 2-((1S)-6-bromo-3,4-dihydro-1H-2-benzopyran-1-yl)ethyl tert-butyl(dimethyl)silyl ether, to yield tert-butyl-[2-(5-chloro-1,3-dihydro-2-benzofuran-1-yl)ethoxy]-dimethylsilane.

Sources & evidence

ORD record
ord-19b22ad728f44f148a483c629d5022cb
Source dataset
uspto-grants-2008_02
Patent number
US07335660B2

Reaction notes

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