2-[(1S)-1-(2-{[tert-Butyl(dimethyl)silyl]oxy}ethyl)-3,4-dihydro-1H-2-benzopyran-6-yl]isothiazolidine 1,1-dioxide → 2-[(1S)-6-(1,1-Dioxido-2-isothiazolidinyl)-3,4-dihydro-1H-2-benzopyran-1-yl]ethanol

HRID 2056770Notes

Reaction equation

HRID 2056770 reaction equation
[Si]([O:8][CH2:9][CH2:10][C@H:11]1[C:16]2[CH:17]=[CH:18][C:19]([N:21]3[CH2:25][CH2:24][CH2:23][S:22]3(=[O:27])=[O:26])=[CH:20][C:15]=2[CH2:14][CH2:13][O:12]1)(C(C)(C)C)(C)C.OCC[C@H]1C2C=CC(C(N)=O)=CC=2CCO1>>[O:27]=[S:22]1(=[O:26])[CH2:23][CH2:24][CH2:25][N:21]1[C:19]1[CH:18]=[CH:17][C:16]2[C@H:11]([CH2:10][CH2:9][OH:8])[O:12][CH2:13][CH2:14][C:15]=2[CH:20]=1

Participants

3

Reactant 2

HCID 693065112-[(1S)-1-(2-{[tert-Butyl(dimethyl)silyl]oxy}ethyl)-3,4-dihydro-1H-2-benzopyran-6-yl]isothiazolidine 1,1-dioxideHCID 69308374(1S)-1-(2-Hydroxyethyl)-3,4-dihydro-1H-2-benzopyran-6-carboxamide

Product 1

HCID 693078202-[(1S)-6-(1,1-Dioxido-2-isothiazolidinyl)-3,4-dihydro-1H-2-benzopyran-1-yl]ethanol

Procedure

Prepared from 2-[(1S)-1-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-3,4-dihydro-1H-2-benzopyran-6-yl]isothiazolidine 1,1-dioxide, as described for the preparation of (1S)-1-(2-hydroxyethyl)-3,4-dihydro-1H-2-benzopyran-6-carboxamide.

Sources & evidence

ORD record
ord-f75592010acf4819b0c3568bba9e6420
Source dataset
uspto-grants-2008_02
Patent number
US07335660B2

Reaction notes

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