Methanesulfonyl chloride → 2-[(1S)-6-(4-Thiomorpholinyl)-3,4-dihydro-1H-2-benzopyran-1-yl]ethyl methanesulfonate
Reaction equation
[N:1]1([C:7]2[CH:8]=[CH:9][C:10]3[C@H:15]([CH2:16][CH2:17][OH:18])[O:14][CH2:13][CH2:12][C:11]=3[CH:19]=2)[CH2:6][CH2:5][S:4][CH2:3][CH2:2]1.[CH3:20][S:21](Cl)(=[O:23])=[O:22].CS(OCC[C@H]1C2C=CC(C(N)=O)=CC=2CCO1)(=O)=O>>[CH3:20][S:21]([O:18][CH2:17][CH2:16][C@H:15]1[C:10]2[CH:9]=[CH:8][C:7]([N:1]3[CH2:2][CH2:3][S:4][CH2:5][CH2:6]3)=[CH:19][C:11]=2[CH2:12][CH2:13][O:14]1)(=[O:23])=[O:22]Participants
4
Reactant 3
Product 1
Procedure
Prepared from 2-[(1S)-6-(4-thiomorpholinyl)-3,4-dihydro-1H-2-benzopyran-1-yl]ethanol and methanesulfonyl chloride, as described for the preparation of 2-[(1S)-6-(aminocarbonyl)-3,4-dihydro-1H-2-benzopyran-1-yl]ethyl methanesulfonate.
Sources & evidence
- ORD record
- ord-fddd84c31a654575be25b0c518846109
- Source dataset
- uspto-grants-2008_02
- Patent number
- US07335660B2
Reaction notes
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