Methanesulfonyl chloride → 2-[(1S)-6-(1H-Pyrazol-1-yl)-3,4-dihydro-1H-2-benzopyran-1-yl]ethyl methanesulfonate
Reaction equation
[N:1]1([C:6]2[CH:7]=[CH:8][C:9]3[C@H:14]([CH2:15][CH2:16][OH:17])[O:13][CH2:12][CH2:11][C:10]=3[CH:18]=2)[CH:5]=[CH:4][CH:3]=[N:2]1.[CH3:19][S:20](Cl)(=[O:22])=[O:21].CS(OCC[C@H]1C2C=CC(C(N)=O)=CC=2CCO1)(=O)=O>>[CH3:19][S:20]([O:17][CH2:16][CH2:15][C@H:14]1[C:9]2[CH:8]=[CH:7][C:6]([N:1]3[CH:5]=[CH:4][CH:3]=[N:2]3)=[CH:18][C:10]=2[CH2:11][CH2:12][O:13]1)(=[O:22])=[O:21]Participants
4
Reactant 3
Product 1
Procedure
Prepared from 2-[(1S)-6-(1H-pyrazol-1-yl)-3,4-dihydro-1H-2-benzopyran-1-yl]ethanol and methanesulfonyl chloride, as described for the preparation of 2-[(1S)-6-(aminocarbonyl)-3,4-dihydro-1H-2-benzopyran-1-yl]ethyl methanesulfonate.
Sources & evidence
- ORD record
- ord-b77d4416d00642518d33b12b82d97100
- Source dataset
- uspto-grants-2008_02
- Patent number
- US07335660B2
Reaction notes
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