Trichloroacetyl chloride → 2,2,2-trichloro-N-isoquinolin-8-ylacetamide

HRID 2056800Notes

Reaction equation

[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[NH2:11])[CH:4]=[CH:3][N:2]=1.[Cl:12][C:13]([Cl:18])([Cl:17])[C:14](Cl)=[O:15]>>[Cl:12][C:13]([Cl:18])([Cl:17])[C:14]([NH:11][C:9]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:10]=1[CH:1]=[N:2][CH:3]=[CH:4]2)=[O:15]

Participants

Reactant 2

HCID 6420Trichloroacetyl chloride

HCID 13927912Isoquinolin-8-amine

Product 1

HCID 220326212,2,2-trichloro-N-isoquinolin-8-ylacetamide

Procedure

The product from Example 57C and trichloroacetylchloride were processed as described in Example 1A to provide the title compound.

Sources & evidence

ORD record: ord-684ad0afe42540ee862ca814aff23345
Source dataset: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07335678B2

Reaction notes

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