HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)benzylamine → N-isoquinolin-8-yl-N'-[4-(trifluoromethyl)benzyl]urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)benzylamine | HCID 76804 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 2,2,2-trichloro-N-isoquinolin-8-ylacetamide | HCID 22032621 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-isoquinolin-8-yl-N'-[4-(trifluoromethyl)benzyl]urea | HCID 10088904 | — |
Reaction Steps
The title compound was prepared using 4-(trifluoromethyl)benzylamine, the product from Example 57D, DBU and the procedure described in Example 1B. MS (ESI+) m/z 346 (M+H)+; 1H NMR (DMSO-d6) δ 9.58 (s, 1H), 9.10 (s, 1H), 8.49 (d, 1H), 8.12 (d, 1H), 7.81-7.54 (m, 7H), 7.20 (t, 1H), 4.47 (d, 2H); Anal. Calcd for C18H14F3N3O.0.2 H2O: C, 61.96, H 4.16, N 12.04. Found: C, 62.06, H 4.23, N 11.91.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07335678B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-acd00f12086149829d0a1885061b68fc |
| Source note | uspto-grants-2008_02 |