HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-(4-bromobenzyl)-N'-isoquinolin-8-ylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Bromobenzylamine | HCID 77571 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 2,2,2-trichloro-N-isoquinolin-8-ylacetamide | HCID 22032621 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(4-bromobenzyl)-N'-isoquinolin-8-ylurea | HCID 9998358 | — |
Reaction Steps
The title compound was prepared using 4-bromobenzylamine, the product from Example 57D, DBU and the procedure described in Example 1B. MS (ESI+) m/z 356 (M+H)+; 1H NMR (DMSO-d6) δ 9.52 (s, 1H), 9.15 (s, 1H), 8.49 (d, 1H), 8.11 (d, 1H), 7.77 (d, 1H), 7.67 (t, 1H), 7.55 (m, 3H) 7.32 (d, 2H), 7.25 (t, 1H), 4.34 (d, 2H); Anal. Calcd for C17H14BrN3O.0.25 H2O.0.16 MeOH: C, 56.34, H, 4.17, N, 11.49. Found C, 56.32, H 4.45, N 11.70.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07335678B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-ac313c298961454385c5acc6898fd15c |
| Source note | uspto-grants-2008_02 |