HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Indazol-4-amine, 1-methyl- → N-[4-(1-azepanyl)-3-fluorobenzyl]-N'-(1-methyl-1H-indazol-4-yl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Indazol-4-amine, 1-methyl- | HCID 153838 | — |
| Reactant | NoName_3327 | HCID 413085 | — |
| Reactant | 1-[2-Fluoro-4-(isocyanatomethyl)phenyl]azepane | HCID 22337588 | — |
| Product | N-[4-(1-azepanyl)-3-fluorobenzyl]-N'-(1-methyl-1H-indazol-4-yl)urea | HCID 22337628 | — |
Reaction Steps
The title compound was prepared using the procedure described in Example 89B using 1-[2-fluoro-4-(isocyanatomethyl)phenyl]azepane and 1-methyl-1H-indazol-4-amine instead of 1-bromo-4-(isocyanatomethyl)benzene and the product from Example 89A. NMR (DMSO-d6) δ 9.03 (s, 1H), 8.19 (s, 1H), 7.67 (d, 1H), 7.24 (t, 1H), 7.12-6.95 (m, 5H), 4.22 (s, 2H), 3.99 (s, 3H), 3.35 (m, 4H), 1.78 (m, 4H), 1.55 (m, 4H); MS (ESI) (M+H)+396.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07335678B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-204050e4d05c415db5065b3ac5227a67 |
| Source note | uspto-grants-2008_02 |