Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → N-[1-(4-bromophenyl)ethyl]-2-(5-isoquinolinyl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4-Bromobenzylamine | HCID 77571 | — |
| 반응물 | 1-(4-Bromophenyl)ethylamine | HCID 91175 | — |
| 반응물 | Methyl 2-(isoquinolin-5-yl)acetate | HCID 22337565 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-[1-(4-bromophenyl)ethyl]-2-(5-isoquinolinyl)acetamide | HCID 22032664 | — |
반응 단계
The title compound was prepared using the procedure described in Example 132C using the product from Example 133B and 1-(4-bromophenyl)ethanamine instead of the product from Example 132B and 4-bromobenzylamine. 1H NMR (300 MHz, d6-DMSO) 9.81 (s, 1H), 9.00 (d, 1H), 8.70 (d, 1H), 8.48 (d, 1H), 840 (d, 1H), 8.04 (d, 1H), 7.92 (m, 1H), 7.51 (d, 2H), 7.23 (d, 2H), 4.84 (m, 1H), 4.10 (s, 2H), 1.35 (d, 3H). MS (DCI/NH3) m/e 369 (M+H)+; Anal. Calcd. For C19H17N2OBr. 1.0 HCl. 1.0 H2O: C 53.86; H 4.76; N 6.61. Found: C 53.47; H 4.53; N 6.76.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07335678B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-b517a7df43d242978ea4f5721c539987 |
| 출처 메모 | uspto-grants-2008_02 |