HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Isocyanatoisoquinoline → N-[4-(1-azocanyl)-3-fluorobenzyl]-N'-(3-methyl-5-isoquinolinyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Isocyanatoisoquinoline | HCID 11586357 | — |
| Reactant | 5-Isocyanato-3-methylisoquinoline | HCID 22228382 | — |
| Reactant | 4-(1-Azocanyl)-3-fluorobenzylamine | HCID 22337574 | — |
| Product | N-[4-(1-azocanyl)-3-fluorobenzyl]-N'-(3-methyl-5-isoquinolinyl)urea | HCID 22032674 | — |
Reaction Steps
The title compound was prepared using the procedure described in Example 61B using 4-(1-azocanyl)-3-fluorobenzylamine and the product from Example 154A instead of 4-cyanobenzyl alcohol and the product from Example 61A. 1H NMR (300 MHz, DMSO-d6) δ 9.70 (s, 1H), 9.37 (s, 1H), 8.56 (m, 2H), 8.01 (d, 1H, J=8.4 Hz), 7.81 (t, 1H, J=8.4 Hz), 7.45 (t, 1H), 7.02 (m, 2H), 6.90 (m, 1H), 4.25 (d, 2H, J=6 Hz), 3.35 (m, 4H), 2.77 (s, 3H), 1.67 (m, 4H), 1.54 (m, 6H); MS (ESI) 421 (M+H)+; Anal. Calcd for C25H29FN4O.HCl: C, 65.71; H, 6.62; N, 12.26. Found: C, 65.44; H, 6.49; N, 12.15.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07335678B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-0f78722dd7d245339ce5ea8f53809ff7 |
| Source note | uspto-grants-2008_02 |