Acetic Anhydride → N-(Isoquinolin-3-yl)acetamide

HRID 2056888Notes

Reaction equation

HRID 2056888 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH3:12][C:13](OC(C)=O)=[O:14]>>[CH:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:11]=[C:2]([NH:1][C:13](=[O:14])[CH3:12])[N:3]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 311869Isoquinolin-3-Amine

Product 1

HCID 12366594N-(Isoquinolin-3-yl)acetamide

Procedure

3-Aminoisoquinoline (495 mg, 3.44 mmol) was stirred in Ac2O (9 mL) at 60° for 16 hours. The mixture was cooled to room temperature and concentrated in vacuo to provide the title compound which was used in the next step without further purification.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-9686a9bdfa9448c18f6ca2229dfee664
Source dataset
uspto-grants-2008_02
Patent number
US07335678B2

Reaction notes

Loading…