HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-5-(trifluoromethyl)benzylamine → HCID 10317373, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-5-(trifluoromethyl)benzylamine | HCID 2733304 | — |
| Reactant | 2-(Isoquinolin-5-YL)acetic acid | HCID 12018708 | — |
| Reactant | 2-(Isoquinolin-5-yl)propanoic acid | HCID 22337638 | — |
| Product | HCID 10317373 | HCID 10317373 | — |
Reaction Steps
The title compound was prepared using the procedure described in Example 222B using 3-fluoro-5-(trifluoromethyl)benzylamine and 2-(5-isoquinolinyl)propanoic acid instead of 4-(trifluoromethoxy)benzylamine and 5-isoquinolinylacetic acid. MS (ESI+) m/z 377 (M+H)+; MS (ESI−) m/z 375 (M−H)−; 1H NMR (DMSO, 300 MHz) δ 1.55 (d, J 7.1, 3H), 4.36 (m, 2H), 4.53 (q, J 7.1, 1H), 7.29 (m, 2H), 7.49 (d, J 8.7, 1H), 7.80 (t, J 7.8, 1H), 7.93 (d, J 6.5, 1H), 8.21 (d, J 8.1, 1H), 8.31 (d, J 6.4, 1H), 8.60 (d, J 6.2, 1H), 8.73 (t, J 5.8, 1H), 9.56 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07335678B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-a631d43c533d4ec48e797b8bbafec982 |
| Source note | uspto-grants-2008_02 |