HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenemethanamine, 2,5-dichloro- → N-(2,5-dichlorobenzyl)-2-(5-isoquinolinyl)propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenemethanamine, 2,5-dichloro- | HCID 457600 | — |
| Reactant | 2-(Isoquinolin-5-YL)acetic acid | HCID 12018708 | — |
| Reactant | 2-(Isoquinolin-5-yl)propanoic acid | HCID 22337638 | — |
| Product | N-(2,5-dichlorobenzyl)-2-(5-isoquinolinyl)propanamide | HCID 10043982 | — |
Reaction Steps
The title compound was prepared using the procedure described in Example 222B using 2,5-dichlorobenzylamine and 2-(5-isoquinolinyl)propanoic acid instead of 4-(trifluoromethoxy)benzylamine and 5-isoquinolinylacetic acid. MS (ESI+) m/z 359 (M+H)+; MS (ESI−) m/z 357 (M−H)−; 1H NMR (DMSO, 300 MHz) δ 1.54 (d, J 7.1, 3H), 4.20 (m, 2H), 4.53 (q, J 7.1, 1H), 7.06 (s, 1H), 7.32 (d, J 8.4, 1H), 7.44 (d, J 8.4, 1H), 7.51 (s, 1H), 7.78 (t, J 7.8, 1H), 7.90 (d, J 6.5, 1H), 8.16 (d, J 8.1, 1H), 8.26 (d, J 6.4, 1H), 8.60 (d, J 6.2, 1H), 8.65 (t, J 5.8, 1H), 9.49 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07335678B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-905ac60bda5447a1a84258d0a3dfebb7 |
| Source note | uspto-grants-2008_02 |