HCID 22337641, compound → HCID 22337569, compound

HRID 2056948Notes

Reaction equation

HRID 2056948 reaction equation
[C:1]([O:4][C:5]1[N:6]=[CH:7][C:8]2[C:13]([CH:14]=1)=[C:12]([N+:15]([O-])=O)[CH:11]=[CH:10][CH:9]=2)(=[O:3])[CH3:2].[H][H]>O1CCOCC1.[Ni]>[C:1]([O:4][C:5]1[N:6]=[CH:7][C:8]2[C:13]([CH:14]=1)=[C:12]([NH2:15])[CH:11]=[CH:10][CH:9]=2)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 22337641HCID 22337641, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22337569HCID 22337569, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 312751,4-DioxaneSolvent

Procedure

5-Nitro-3-isoquinolinyl acetate (50 mg, 0.21 mmol) in 1,4-dioxane (20 mL) was treated with Raney-nickel powder (85 mg) and exposed to a hydrogen atmosphere via a balloon for 16 hours. The mixture was filtered through a plug of Celite and the filtrate was concentrated under reduced pressure to provide the title compound which was used without further purification.

Workup

  1. filtrationThe mixture was filtered through a plug of Celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-3865fc75690b424194ca0c7e00479ff1
Source dataset
uspto-grants-2008_02
Patent number
US07335678B2

Reaction notes

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