HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dimethoxybenzene → HCID 11656000, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dimethoxybenzene | HCID 9025 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 6-chloro-N-(3-chloro-4-methoxyphenyl)-N'-cycloheptyl-[1,3,5]triazine-2,4-diamine | HCID 21897021 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | HCID 11656000 | HCID 11656000 | 64% |
Reaction Steps
A mixture of compound 133 (0.5 grams), 1,3-dimethoxybenzene (0.18 g) and AlCl3 (0.2 grams) in dichloroethane (10 mL) was stirred under nitrogen atmosphere at room temperature for 30 min. It was then heated at 80° C. for 3 hours with stirring. The reaction mixture was poured into ice-cold water (50 mL), extracted with chloroform (3×30 mL), dried over anhydrous Na2SO4 and concentrated under vacuum. The residue thus obtained was purified by column chromatography using petroleum ether-ethyl acetate to afford the expected product (yield 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07335770B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-2d9150f159e945eab6360e91966e47af |
| Source note | uspto-grants-2008_02 |