1,3,5-Trimethoxybenzene → HCID 11663517, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of compound 133 (0.5 grams), 1,3,5-trimethoxybenzene (0.2 grams) and AlCl3 (0.2 grams) in dichloroethane (10 mL) was stirred under nitrogen atmosphere. It was then heated at 80° C. for 3 hours. The reaction mixture was poured into ice-cold water (50 mL), extracted with chloroform and the organic layer was washed with water followed by concentration. The residue thus obtained was purified by column chromatography using petroleum ether-ethyl acetate to afford the N-(3-Chloro-4-methoxy-phenyl)-N′-cycloheptyl-6-(2,4,6-trimethoxy-phenyl)-[1,3,5]triazine-2,4-diamine.

Provenance & Evidence