HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dibromobutane → (1R,2S)-1,2-Diphenyl-2-piperidin-1-yl-ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dibromobutane | HCID 8056 | — |
| Reactant | 1,5-Dibromopentane | HCID 8100 | — |
| Reactant | (1R,2S)-2-Amino-1,2-diphenylethanol | HCID 719819 | — |
| Reactant | HCID 10856884 | HCID 10856884 | — |
| Solvent | Hexane | HCID 8058 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (1R,2S)-1,2-Diphenyl-2-piperidin-1-yl-ethanol | HCID 23251237 | 91% |
Reaction Steps
Repeat Step (a) of EXAMPLE 6, but replace (1R,2S)-2-amino-1-phenyl-3-methyl-butanol with (1R,2S)-2-amino-1,2-diphenyl-ethanol, and replace 1,4-dibromobutane with 1,5-dibromopentane. Column chromatography (Silica gel 50 g, eluent is n-Hexane:EtOAc=5:1) is used to purify the coarse product and a white solid (1.28 g) is obtained. The yield is 91% and the other analysis includes:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07335781B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-dbb0a5219dd449938eda2e8b584573b7 |
| Source note | uspto-grants-2008_02 |