4-Nitrobenzenesulfonyl chloride → HCID 178484851, compound

HRID 2057233Notes

Reaction equation

HRID 2057233 reaction equation
Cl.[Br:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([NH:14][CH3:15])[CH2:10][CH2:9]1.[N+:16]([C:19]1[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=1)([O-:18])=[O:17]>>[Br:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][C@H:8]1[CH2:9][CH2:10][C@H:11]([N:14]([CH3:15])[S:25]([C:22]2[CH:21]=[CH:20][C:19]([N+:16]([O-:18])=[O:17])=[CH:24][CH:23]=2)(=[O:26])=[O:27])[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 74044-Nitrobenzenesulfonyl chlorideHCID 178484847HCID 178484847, compound

Product 1

HCID 178484851HCID 178484851, compound

Procedure

In analogy to example 11.9, trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine hydrochloride and 4-nitro-benzenesulfonyl chloride (with 2.1 eq N,N-diisopropylethylamine) were reacted to yield trans-N-[4-(4-Bromo-butoxy)-cyclohexyl]-N-methyl-4-nitro-benzenesulfonamide, MS: 451 (MH+).

Sources & evidence

ORD record
ord-0143866dd22a444189b42199b3c10d53
Source dataset
uspto-grants-2008_02
Patent number
US07335687B2

Reaction notes

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