Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | HCID 178484793 | HCID 178484793 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | HCID 178484794 | HCID 178484794 | 109% |
Reaction Steps
A solution of 250 mg (0.59 mmol) of trans-N-[4-(5-Chloro-pent-1-ynyl)-cyclohexyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide in 10 ml butan-2-one was treated with 136 mg of NaI (0.91 mmol) and heated at 80° C. for 48 h. Evaporation gave 330 mg of crude trans-N-[4-(5-Iodo-pent-1-ynyl)-cyclohexyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide which was used directly for the next step, MS: 514 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07335687B2 |
|---|
| Source dataset | uspto-grants-2008_02 |
|---|
| ORD ID | ord-7d84a8da8c38446782c9d258f85dfc48 |
|---|
| Source note | uspto-grants-2008_02 |
|---|
