Bis(2-chloroethyl)amine → HCID 20332012, compound

Participants

Reaction Steps

A mixture of 9 parts of 2-chloro-N-(2-chloroethyl)ethanamine hydrochlorine, 12.7 parts of 3-chloro-4-(4-chlorophenoxy)-benzenamine and 28 parts n-butanol is stirred and refluxed for 24 hours. The mixture is cooled and 3.5 parts of potassium carbonate are added. Stirring is continued for another 24 hours at reflux. The reaction mixture is filtered hot and the product is crystallized after cooling the filtrate. 2,2'-Oxybispropane is added and the precipitated product is filtered off. It is crystallized from a mixture of 2-propanol and 2,2'-oxybispropane, yielding 10.5 parts of 1-[3-chloro-4-(4-chlorophenoxy)phenyl]piperazine hydrochloride; mp. 187.7° C.

Provenance & Evidence