Sodium Carbonate → HCID 20332025, compound

Participants

Reaction Steps

8.6 gm of 11-chloroacetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one, 3.5 gm of sodium carbonate and 4.5 gm of hexahydro-1-methyl-1H-1, 4-diazepine were refluxed in 100 ml of ethanol for 2.5 hours. Then the hot mixture was suction-filtered, the alcohol was distilled off, and the residue was triturated with dioxane. The precipitated crystals were dissolved in ethanol and converted into the dihydrochloride by addition of concentrated hydrochloric acid. After recrystallization from 94% ethanol:

Provenance & Evidence