m-Chloroperbenzoic acid → 3-Chlorobenzoic Acid

Participants

Reaction Steps

A solution of (e3) (0.3 g) in water (10 ml) was treated with solid m-chloroperbenzoic acid (0.17 g). A white precipitate of m-chlorobenzoic acid was rapidly formed, and after 10 minutes was filtered off. The remaining solution was neutralised to pH 7 with sodium bicarbonate and then chromatographed on QAE sephadex A 25 eluting with NaCl--phosphate buffer. The product was desalted on Amberlite XAD 4 using distilled water to elute, and then freeze-dried to afford a mixture of sulphoxides (1.2:1) (e4) as a white solid (0.176 g, 57%).

Provenance & Evidence