Acetic Acid → Hydrochloric Acid

Participants

Reaction Steps

Following the procedure of Example 2, 6-chloro-4-cyano-4-trimethylsilyloxy-3,4-dihydro-2H-naphtho[1,2-b]pyran (0.52 g.), stannous chloride dihydrate (1.94 g.) were reacted in glacial acetic acid (5 ml.) and concentrated hydrochloric acid (5 ml.) to form 6-chloro-3,4-dihydro-2H-naphtho[1,2-b]pyran-4-carboxylic acid. Recrystallization from ethyl acetate-hexane yielded 0.23 g. of product, m.p. 141°-142° C.

Provenance & Evidence