HCID 12552203, compound → HCID 20332218, compound

Participants

Reaction Steps

A catalyst of 10% palladium on charcoal (Engelhard 4505, 50 mg) suspended in 90% aqueous ethanol (10 ml) was prehydrogenated for 20 minutes at room temperature/atmospheric pressure. Benzyl 7-oxo-3-p-nitrophenylthio-1-azabicyclo [3.2.0]hept-2-ene-2-carboxylate (50 mg) partially dissolved in ethanol (10 ml) was added, and the mixture was hydrogenated at room temperature and atmospheric pressure for 1.5 hours. The catalyst was removed by filtration through "High-Flo", and the colourless filtrate was evaporated to give an oil (35 mg) identical by TLC, u.v. and I.R. to the product (22) obtained in Example 7.

Provenance & Evidence