HCID 12767988, compound → HCID 70567225, compound

HRID 2057447Notes

Reaction equation

HRID 2057447 reaction equation
[OH:1][CH2:2][C:3]1[CH2:4][S:5][C@@H:6]2[CH:13]([NH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[C:12](=[O:22])[N:7]2[C:8]=1[C:9]([O-:11])=[O:10].[K+].ClC(Cl)(Cl)C[O:27][C:28]([N:30]=C=O)=O>>[C:28]([O:1][CH2:2][C:3]1[CH2:4][S:5][C@@H:6]2[CH:13]([NH:14][C:15]([O:17][C:18]([CH3:19])([CH3:21])[CH3:20])=[O:16])[C:12](=[O:22])[N:7]2[C:8]=1[C:9]([OH:11])=[O:10])(=[O:27])[NH2:30]

Participants

3

Reactant 2

HCID 12767988HCID 12767988, compoundHCID 70568125HCID 70568125, compound

Product 1

HCID 70567225HCID 70567225, compound

Procedure

5 g. of potassium 3-hydroxymethyl-7-[N-(t-butoxycarbonyl)amino]-3-cephem-4-carboxylate is reacted with 2,2,2-trichloroethoxycarbonyl isocyanate and the resulting product is deblocked following the procedures described in Example 5 to afford 3-carbamoyloxymethyl-7-[N-(t-butoxycarbonyl)amino]-3-cephem-4-carboxylic acid.

Sources & evidence

ORD record
ord-57078aba3b164cf89f3bb59936ea9d35
Source dataset
uspto-grants-1980_07
Patent number
US04210750

Reaction notes

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