4-Chlorobenzoic acid, 4-nitrophenyl ester → Moclobemide

HRID 2057458노트

반응식

HRID 2057458 반응식
[N+](C1C=CC(O[C:11](=[O:19])[C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)=CC=1)([O-])=O.[NH2:20][CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1>O1CCCC1>[Cl:18][C:15]1[CH:14]=[CH:13][C:12]([C:11]([NH:20][CH2:21][CH2:22][N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)=[O:19])=[CH:17][CH:16]=1

참가 물질

4

반응물 2

HCID 2536574-Chlorobenzoic acid, 4-nitrophenyl esterHCID 4082852-Morpholinoethylamine

생성물 1

HCID 4235Moclobemide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

5.55 G. of p-chlorobenzoic acid p-nitrophenyl ester are added to a solution of 2.6 g. of N-(2-aminoethyl)-morpholine in 100 ml. of tetrahydrofuran and the mixture is allowed to stand overnight at room temperature. It is then evaporated to dryness and the residue is taken up in 200 ml. of methylene chloride. The methylene chloride solution is washed three times with 50 ml. of a 1% sodium hydroxide solution each time and twice with 50 ml. of water each time until neutral, dried over sodium sulfate and evaporated to dryness. The residue is recrystallized from isopropanol, and 3.1 g. of p-chloro-N-(2-morpholinoethyl)-benzamide are obtained, which is identical to the product obtained in Example 1.

후처리

  1. customIt is then evaporated to dryness
  2. washThe methylene chloride solution is washed three times with 50 ml
  3. dry with materialof water each time until neutral, dried over sodium sulfate
  4. customevaporated to dryness
  5. customThe residue is recrystallized from isopropanol, and 3.1 g

출처 및 근거

ORD 기록
ord-c23f06a13a094744bea401b8f655a3b7
출처 데이터셋
uspto-grants-1980_07
특허 번호
US04210754

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