Hydrogen Bromide → HCID 86737079, compound

Participants

Reaction Steps

Ethyl-N-[bis(methylthio)phosphinothioylmethyl]-N-(benzyloxycarbonyl)glycine (5.9 g.) was dissolved in 11 ml. of 35% hydrobromic acid in acetic acid and stirred for one hour. Ether was added to the reaction solution which precipitated ethyl-N-[bis(methylthio)phosphinothioylmethyl]glycine hydrobromide salt as an oily liquid. This oil was washed three more times with additional ether. The material was suspended in benzene and treated with propylene oxide which effected almost complete solution. The solution was then concentrated to an oil at 0.5 torr. The oil thus recovered was chromatographed on 25 g. of silica gel employing diethyl ether as the eluant to yield ethyl-N-[bis(methylthio)phosphinothioylmethyl]glycine (1.46 g.) as an oil, ND25 =1.6002.

Provenance & Evidence