Acetylacetone → Ethanone, 1-(4-amino-5-(4-fluorophenyl)-2-methyl-1H-pyrrol-3-yl)-

HRID 2057530Notes

Reaction equation

[NH2:1][CH:2]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)[C:3]#[N:4].[C:12]([CH2:15][C:16](=O)[CH3:17])(=[O:14])[CH3:13]>>[C:12]([C:15]1[C:3]([NH2:4])=[C:2]([C:5]2[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=2)[NH:1][C:16]=1[CH3:17])(=[O:14])[CH3:13]

Participants

Reactant 2

HCID 31261Acetylacetone

HCID 27359222-Amino-2-(4-fluorophenyl)acetonitrile

Product 1

HCID 41885Ethanone, 1-(4-amino-5-(4-fluorophenyl)-2-methyl-1H-pyrrol-3-yl)-

Procedure

Starting from 2-amino-2-(p-fluorophenyl)acetonitrile and acetylacetone, the open-chain intermediate compound is obtained; b.p. 150° C./0.3 mm Hg. Overall yield of the title compound: 47%, m.p. 211°-12° C. (from ethanol).

Workup

customthe open-chain intermediate compound is obtained

Sources & evidence

ORD record: ord-e4fee97b3fd74c2b820e9c274f252c0c
Source dataset: uspto-grants-1980_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04211709

Reaction notes

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