Phosphorus tribromide → 1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-

HRID 2057549Notes

Reaction equation

HRID 2057549 reaction equation
O[CH2:2][CH2:3][N:4]1[C:8](=[O:9])[C:7]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:6]2[C:5]1=[O:14].P(Br)(Br)[Br:16]>>[Br:16][CH2:2][CH2:3][N:4]1[C:8](=[O:9])[C:7]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:6]2[C:5]1=[O:14]

Participants

3

Reactant 2

HCID 24614Phosphorus tribromideHCID 77499N-(2-Hydroxyethyl)phthalimide

Product 1

HCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-

Procedure

A mixture of 5.35 g (0.028 mol) of N-(2-hydroxyethyl)phthalimide and 7.7 g (0.028 mol) of phosphorus tribromide is warmed until solution is obtained. The reaction mixture is then cooled and poured into ice water. The resulting solid is collected by filtration and washed with water to give N-(2-bromoethyl)phthalimide.

Workup

  1. temperatureis warmed until solution
  2. customis obtained
  3. temperatureThe reaction mixture is then cooled
  4. filtrationThe resulting solid is collected by filtration
  5. washwashed with water

Sources & evidence

ORD record
ord-cf82ed66adf44d738ad6b63a4c283df9
Source dataset
uspto-grants-1980_07
Patent number
US04211703

Reaction notes

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