1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- → 2-(2-Diethoxyphosphorylethyl)isoindole-1,3-dione

Participants

Reaction Steps

A mixture of 5.32 g (0.017 mol) of N-(2-bromoethyl)phthalimide and 2.74 g (0.017 mol) of triethyl phosphite is heated gently to initiate reaction. After the reaction subsides, heating is continued for 1 hour with distillation of ethyl bromide. Chloroform is added to the cooled mixture and the solution is washed with water. The organic phase is dried and concentrated to give diethyl phthalimidoethylphosphonate.

Provenance & Evidence