反应详情

0.072 mol (12.6 g) of 4-chloro-2-nitrophenol, 40 ml of acetone and 9.72 g of potassium carbonate are introduced into a 250 ml three-necked flask equipped with a stirring system, a thermometer and a condenser. The mixture is brought to 40° C. and 9.72 g of dimethyl sulphate are then added drop by drop; the mixture is heated under reflux for 5 hours; the potassium sulphate is separated; the acetone solution is concentrated under reduced pressure and the 4-chloro-2-nitroanisole is precipitated. It is separated and then crystallized in a water/acetone mixture.

1. customequipped with a stirring system
2. customis brought to 40° C.
3. temperaturethe mixture is heated
4. temperatureunder reflux for 5 hours
5. customthe potassium sulphate is separated
6. concentrationthe acetone solution is concentrated under reduced pressure
7. customthe 4-chloro-2-nitroanisole is precipitated
8. customIt is separated
9. customcrystallized in a water/acetone mixture