HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → N-(5-Chloro-2-methoxyphenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 5-Chloro-2-methoxyaniline | HCID 66763 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Product | N-(5-Chloro-2-methoxyphenyl)acetamide | HCID 346203 | — |
Reaction Steps
0.2 mol (31.5 g) of 2-amino-4-chloroanisole, 40 ml of absolute alcohol, 20 ml of acetic anhydride and a pinch of zinc powder are placed in a 150 ml flask; the solution is brought to reflux for 30 minutes. The reaction liquid is poured onto crushed ice. The product obtained is separated; it is crystallized in a methanol/water mixture (20/80).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04211776 |
| Source dataset | uspto-grants-1980_07 |
| ORD ID | ord-c42d966b02af44adb9dfab5d9b71aeeb |
| Source note | uspto-grants-1980_07 |