N1-(5-chloro-2-methoxy-4-nitrophenyl)acetamide → 5-Chloro-4-nitro-o-anisidine

HRID 2057573Notes

Reaction equation

HRID 2057573 reaction equation
C([NH:4][C:5]1[CH:10]=[C:9]([Cl:11])[C:8]([N+:12]([O-:14])=[O:13])=[CH:7][C:6]=1[O:15][CH3:16])(=O)C>[OH-].[K+]>[NH2:4][C:5]1[CH:10]=[C:9]([Cl:11])[C:8]([N+:12]([O-:14])=[O:13])=[CH:7][C:6]=1[O:15][CH3:16]

Participants

3

Reactant 1

HCID 2775778N1-(5-chloro-2-methoxy-4-nitrophenyl)acetamide

Product 1

HCID 804105-Chloro-4-nitro-o-anisidine

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

0.5 mol (99.5 g) of 2-acetamido-4-chloro-5-nitroanisole and 125 ml of a solution of potassium hydroxide (140 g of KOH/100 ml of water) are introduced into a 500 ml flask; the mixture is brought to between 100° and 110° C. for one hour and three quarters; the product is dried without heating and washed with water.

Workup

  1. customthe product is dried
  2. temperaturewithout heating
  3. washwashed with water

Sources & evidence

ORD record
ord-c6dbbc4a161a46cb97be7a9cb9ce295a
Source dataset
uspto-grants-1980_07
Patent number
US04211776

Reaction notes

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