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HRID2057583

反应详情

EQUATION

反应方程式

HRID 2057583 的结构方程式

REACTANTS

反应物

1
结构：CC(=O)O[C@H]1[C@H](F)[C@H](n2cc(C)c(=O)[nH]c2=O)O[C@@H]1COC(=O)c1ccccc1
HCID54100196

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2F)c(=O)[nH]c1=O
HCID72327

未命名化合物

收率 83.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：N
溶剂HCID222

Ammonia gas

H3N

PROCEDURE

实验过程

1-(3-O-Acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine (150 mg) is dissolved in saturated methanolic ammonia (15 ml), and the mixture left standing for 16 hours. The solvent is removed by evaporation in vacuo, and the residue crystallized from water to give 80 mg of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine, m.p. 185°-185.5°.

WORKUP

后处理

  1. waitthe mixture left
  2. customThe solvent is removed by evaporation in vacuo
  3. customthe residue crystallized from water